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Spruce Biosciences Inc
611 Gateway Boulevard, Suite 740
Phone: (415) 655-4168p:415 655-4168 SOUTH SAN FRANCISCO, CA  94080  United States Ticker: SPRBSPRB
Business Summary
Spruce Biosciences, Inc. is a late-stage biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. The Company has acquired an exclusive worldwide license agreement for tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B (MPS IIIB). The TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) with modified human insulin-like growth factor 2 via an amino acid linker. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. The Company's pipeline also includes Tildacerfont and Cortibon for the treatment of Major Depressive Disorder, SPR202 for the treatment of Congenital Adrenal Hyperplasia and SPR204 for the treatment of Post-Bariatric Hypoglycemia.

Scores and Ratings
FRISK®
Score		 Z''
Score		 PAYCE®
Score		 DBT
Index		 Moody's
Rating		 Fitch
Rating		 DBRS
Rating
YesYes-Yes---

Financials, News and Filings
Latest
Statement		 Last
Audit
News		 SEC
Filings		 Bankruptcy
Filings		 Suit &
Judgment
Filings		 Tax
Lien
Filings
12/31/202412/31/2024YesYes---

Industries
SIC Code Description
8731 Commercial physical and biological research
2834 Pharmaceutical preparations

Officers and Directors

Title
Name
Age		 Title
Date		 Start
Date
Executive Chairman of the Board Michael G.Grey 71 1/3/2022 1/1/2016
President, Chief Financial Officer Samir M.Gharib 41 1/1/2022 5/1/2020
Chief Executive Officer, Director JavierSzwarcberg 54 1/3/2022 1/1/2022
6 additional Officers and Directors records available in full report.

General Information
Number of Employees: 21 (As of 12/31/2024)
Outstanding Shares: 42,231,285 (As of 4/11/2025)
Shareholders: 33
Stock Exchange: NASD
Federal Tax Id: 812154263
Fax Number: (302) 636-5454


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