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Actuate Therapeutics Inc
1751 RIVER RUN, SUITE 400
Phone: (847) 986-4190p:847 986-4190 FORT WORTH, TX  76107  United States Ticker: ACTUACTU
Business Summary
Actuate Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing therapies for the treatment of high impact, difficult to treat cancers through the inhibition of glycogen synthase kinase-3 (GSK-3). The Company is developing elraglusib, a small molecule that is designed to enter cancer cells and block the function of the enzyme GSK-3b, a master regulator of complex biological signaling cascades, including those mediated by oncogenes, that lead to tumor cell survival, growth, migration, and invasion. Its lead program, Elraglusib Injection, is an intravenous solution of elraglusib for the treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC). Elraglusib Injection has been evaluated in a Phase I dose escalation study (Actuate-1801 Part 1) in 238 adult patients. Elraglusib is designed to act as a mediator of anti-tumor immunity through the inhibition of NF-kB and regulates multiple immune checkpoints and immune cell function.

Scores and Ratings
FRISK®
Score		 Z''
Score		 PAYCE®
Score		 DBT
Index		 Moody's
Rating		 Fitch
Rating		 DBRS
Rating
-Yes-Yes---

Financials, News and Filings
Latest
Statement		 Last
Audit
News		 SEC
Filings		 Bankruptcy
Filings		 Suit &
Judgment
Filings		 Tax
Lien
Filings
6/30/202412/31/2023YesYes---

Industries
SIC Code Description
8731 Commercial physical and biological research

Officers and Directors

Title
Name
Age		 Title
Date		 Start
Date
Chairman of the Board Aaron G.Fletcher 43 4/1/2015 4/1/2015
President, Chief Executive Officer, Director Daniel M.Schmitt 62 4/1/2015 3/1/2015
Chief Financial Officer PaulLytle 56 6/1/2024 2/1/2024
5 additional Officers and Directors records available in full report.

Business Names
Business Name
ACTU
Actuate Therapeutics LTD

General Information
Number of Employees: 11 (As of 6/30/2024)
Outstanding Shares: 19,531,636 (As of 9/23/2024)
Stock Exchange: NASD
Federal Tax Id: 473044785


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Wednesday, November 20, 2024