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Upstream Bio Inc
890 Winter Street, Suite 200
Phone: (781) 208-2466p:781 208-2466 WALTHAM, MA  02451  United States Ticker: UPBUPB
Business Summary
Upstream Bio, Inc. is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The Company is developing verekitug, the only known antagonist in development that targets the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. TSLP is a member of a class of epithelial cytokines, also including IL-25 and IL-33, referred to as alarmins. TSLP is primarily produced by epithelial cells, especially in the lung, gastrointestinal tract and skin. The Company has advanced this highly potent monoclonal antibody into separate Phase II trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) and plans to initiate development of chronic obstructive pulmonary disease (COPD).

Scores and Ratings
FRISK®
Score		 Z''
Score		 PAYCE®
Score		 DBT
Index		 Moody's
Rating		 Fitch
Rating		 DBRS
Rating
YesYes-Yes---

Financials, News and Filings
Latest
Statement		 Last
Audit
News		 SEC
Filings		 Bankruptcy
Filings		 Suit &
Judgment
Filings		 Tax
Lien
Filings
9/30/202412/31/2023YesYes---

Industries
SIC Code Description
2834 Pharmaceutical preparations
8731 Commercial physical and biological research

Officers and Directors

Title
Name
Age		 Title
Date		 Start
Date
Independent Chairman of the Board Ronald C.Renaud 55 11/1/2021 11/1/2021
Chief Executive Officer, Director E. RandSutherland 55 4/1/2024 4/1/2024
Chief Financial Officer, Chief Operating Officer Michael P.Gray 53 3/1/2024 3/1/2024
6 additional Officers and Directors records available in full report.

Business Names
Business Name
UPB
Upstream Bio Securities Corporation

General Information
Number of Employees: 38 (As of 8/1/2024)
Outstanding Shares: 53,596,601 (As of 11/5/2024)
Stock Exchange: NASD
Fax Number: (302) 636-5454


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Wednesday, November 20, 2024